March 1, 1987HypertensionOpen Access

Paroxysmal hypertension due to sinoaortic baroreceptor denervation in humans.

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Population

1 adult male with a remote history of neck and mediastinal radiation, presenting with severe paroxysms of…

Design

Case_report

Authors

TATimothy R. AksamitMayo Clinic in Arizona JFJ S FlorasToronto Western Hospital RVRonald G. VictorPennington Biomedical Research Center

Discussion

Member takes

Implication

Alerts to baroreflex failure in post-radiation paroxysmal hypertension; leaves open generalizability and management implications.

Structured PICO

Population

1 adult male (41 years old) with a remote history of neck and mediastinal radiation, presenting with severe paroxysms of hypertension, headache, and cutaneous flushing after bilateral carotid bypass surgery.

Intervention

Systematic evaluation of arterial and cardiopulmonary baroreceptor reflex function using phenylephrine, nitroprusside, and lower body negative pressure.

Outcome

Changes in heart rate, arterial pressure, and efferent muscle sympathetic nerve activity.surrogate

Paroxysmal hypertension can result from spontaneous fluctuations in central sympathetic drive unbuffered by arterial baroreceptors due to sinoaortic denervation from radiation and surgery.

Cite This Study

Aksamit et al. (1987) studied this question.

synapsesocial.com/papers/6a79323214b028facf0da050 https://doi.org/10.1161/01.hyp.9.3.309

Topics

Hypertension management

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Paroxysmal hypertension due to sinoaortic baroreceptor denervation in humans.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Paroxysmal hypertension due to sinoaortic baroreceptor denervation in humans.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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