Unloading arterial baroreceptors causes neurogenic hypertension

Dogs with denervated baroreceptors in the aortic arch and one carotid sinus, with catheters implanted in the descending aorta and common carotid arteries (n=10 total)

Baroreceptor unloading induced by ligation of the common carotid artery proximal to the innervated sinus for 7 days

5-day control period (baseline) and a separate control group with ligation of the carotid below a denervated sinus (n=4)

Mean arterial pressure (MAP) and carotid sinus pressure (CSP)surrogate