Why the study?
Head and neck tumors can interrupt or abnormally increase afferent baroreceptor signaling, causing erratic blood pressure, but the cardiovascular autonomic features arising from afferent baroreceptor neuron injury or compression needed characterization.
Population
23 patients with afferent baroreflex dysfunction
Design
Case series
Authors
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Clinicians should consider these phenotypes in unexplained BP lability or syncope; case reports leave open questions of prevalence and management.
Afferent baroreflex dysfunction presents with distinct cardiovascular autonomic phenotypes depending on whether signaling is decreased or excessive, and its prevalence appears to be increasing in middle-aged men due to HPV-related oropharyngeal cancer.
Norcliffe‐Kaufmann et al. (2020) studied this question.
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