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Recognition of ketosis-prone type 2 diabetes may guide initial management in adults with hyperglycemic ketosis; retrospective data leaves open optimal long-term strategies.
Ketosis-prone type 2 diabetes is a unique and underrecognized clinical entity characterized by new adult onset of diabetes with severe hyperglycemia and ketosis similar to type 1 diabetes, but with clinical and biological features typical of type 2 diabetes (1). Hyperglycemic crisis with ketosis in these individuals appears to be related to acute and reversible β-cell dysfunction with subsequent insulin independence and acceptable glycemic control on diet and/or oral agents during follow-up (2). In our retrospective study spanning from 1999 to 2011, we identified 62 adult veterans with new onset of diabetes presenting to the VA Greater Los Angeles Healthcare System (VAGLA) with diabetic ketoacidosis (DKA). Computerized medical records were used to identify DKA admissions. Diagnosis of DKA was established in the emergency room (3) in the absence of concomitant comorbidities that can lead …
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Goodstein et al. (2014) studied this question.
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