November 16, 2017Scientific ReportsOpen Access

Pyridoxamine improves survival and limits cardiac dysfunction after MI

View Full Paper

Ask AI

Bookmark

Why the study?

Does pyridoxamine improve survival and limit adverse left ventricular remodeling in a rat model of myocardial infarction?

Population

35 Sprague-Dawley male rats subjected to left anterior descending coronary artery ligation or Sham surgery…

Comparison

Pyridoxamine 1 g/L in drinking water, started 1… vs Placebo in animals undergoing LAD ligation or…

Design

Preclinical, Randomly assigned into 3 groups

Follow-up

8 weeks post-surgery

Authors

DDDorien DeluykerHasselt University VFVesselina FerferievaHasselt University RDRonald B. DriesenZiekenhuis Oost-Limburg

Discussion

Member takes

Implication

PM may limit post-MI remodeling in rats; leaves open whether AGE inhibition improves human HF outcomes.

Structured PICO

Does pyridoxamine improve survival and limit adverse left ventricular remodeling in a rat model of myocardial infarction?

Population

35 Sprague-Dawley male rats (175-200 g) subjected to left anterior descending coronary artery (LAD) ligation (MI) or Sham surgery, plus 7 additional Sham-operated rats pre-treated with PM.

Intervention

Pyridoxamine (PM) 1 g/L in drinking water, started 1 week prior to surgery and continued for 8 weeks post-surgery.

Comparator

Placebo (drinking water alone) in animals undergoing LAD ligation (MI) or Sham surgery.

Outcome

Survival rate, cardiac function (echocardiography and hemodynamics), and collagen content at 8 weeks post-surgery.surrogate

Pyridoxamine treatment improves survival and limits adverse cardiac remodeling and diastolic dysfunction in a rat model of myocardial infarction by reducing AGEs and collagen cross-linking.

Limitations

Lack of evaluation of cardiomyocyte remodeling in both peri-infarct and remote area
Precise quantification of infarct size using TTC staining in all animals was not performed

Cite This Study

Deluyker et al. (2017) studied this question.

synapsesocial.com/papers/6a73abd7d3d4e530dbfb765e https://doi.org/10.1038/s41598-017-16255-y

Topics

Echocardiography

View Full Paper

Ask AI

Bookmark

Pyridoxamine improves survival and limits cardiac dysfunction after MI

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Pyridoxamine improves survival and limits cardiac dysfunction after MI

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider