Why the study?
Do CYP4F2 gene polymorphisms affect the risk of coronary heart disease in a Chinese Han population?
Do CYP4F2 gene polymorphisms affect the risk of coronary heart disease in a Chinese Han population?
CYP4F2 genetic polymorphisms, specifically the GGGT haplotype, are associated with a significantly increased risk of coronary heart disease in the Chinese Han population.
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CYP4F2 haplotypes should not yet inform CHD risk assessment in Chinese Han; observational data leaves open need for prospective validation.
BACKGROUND: To explore the relationship between CYP4F2 gene polymorphism and coronary heart disease (CHD) in a Chinese Han population. METHODS: We selected 440 CHD patients and 440 control subjects to perform a case - control study. Four SNPs (rs2108622, rs3093100, rs3093105 and rs3093135) in CYP4F2 gene were genotyped using polymerase chain reaction - restriction fragment length polymorphism (PCR - RFLP) methods. The genotype and haplotype distributions were compared between the case and the control group. RESULTS: We found both rs2108622 and rs3093105 in CYP4F2 gene were associated with the risk for CHD (P <0.01). Haplotype analysis indicated that GGGT haplotype consisted by rs2108622-rs3093100-rs3093105-rs3093135 was associated with CHD risk (OR = 4.367, 95% CI: 2.241 ~ 8.510; P < 0.001), but GGTA haplotype was associated with decreased risk for CHD (OR = 0.450, 95% CI: 0.111 ~ 0.777; P <0.001). CONCLUSION: CYP4F2 gene polymorphisms were associated with the risk of CHD in Chinese population.
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Yu et al. (2014) studied this question.
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