Key result
In women of the Xinjiang Han population, the CC genotype of the CYP2C9 gene (rs2475376) was significantly associated with an increased risk of coronary artery disease (OR 2.427).
Why the study?
Are CYP2C9 gene polymorphisms associated with coronary artery disease in the Xinjiang Han population?
Case-Control (n=521)
No
Are CYP2C9 gene polymorphisms associated with coronary artery disease in the Xinjiang Han population?
The CC genotype of rs2475376 and the C-C-A-T haplotype in the CYP2C9 gene may serve as genetic risk markers for coronary artery disease in Han Chinese women.
Answers are grounded in this paper and cite their sources.
May flag genetic CAD risk in Han women; hypothesis-generating and should not yet alter practice or screening.
BACKGROUND: Cytochrome P450 (CYP) 2C9 is expressed in the vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs), which have the crucial role in the modulation of cardiovascular homeostasis. We sought to assess the association between the human CYP2C9 gene and coronary artery disease (CAD) in Xinjiang Han Population of China. METHODS: 301 CAD patients and 220 control subjects were genotyped for 4 single-nucleotide polymorphisms (SNPs) of the human CYP2C9 gene (rs4086116, rs2475376, rs1057910, and rs1934967) by a Real-Time PCR instrument. The datas were assessed for 3 groups: total, men, and women via diplotype-based case-control study. RESULTS: For women, the distribution of genotypes, dominant model and alleles of SNP2 (rs2475376) showed significant difference between the CAD patients and control participants (p = 0.033, P = 0.010 and p = 0.038, respectively). The significant difference of the dominant model (CC vs CT + TT) was retained after adjustment for covariates in women (OR: 2.427, 95% confidence interval [CI]: 1.305-4.510, p = 0.005). The haplotype (C-T-A-C) and the diplotypes (CTAC/CTAC) in CYP2C9 gene were lower in CAD patients than in control subjects (p* = 0.0016, and p* = 0.036 respectively). The haplotype (C-C-A-T) was higher in the CAD patients than in the control subjects in women (p* = 0.016). CONCLUSIONS: CC genotype of rs2475376 and C-C-A-T haplotype in CYP2C9 may be a risk genetic marker of CAD in women. T allele of rs2475376, the haplotype (C-T-A-C) and the diplotype (CTAC/CTAC) could be protective genetic markers of CAD for women in Han population of China.
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Fu et al. (2014) conducted a case-control in Coronary artery disease (n=521). CYP2C9 gene polymorphisms (rs2475376 CC genotype) vs. CT + TT genotypes was evaluated on Risk of coronary artery disease associated with the dominant model (CC vs CT + TT) of rs2475376 in women (OR 2.427, 95% CI 1.305-4.510, p=0.005). In women of the Xinjiang Han population, the CC genotype of the CYP2C9 gene (rs2475376) was significantly associated with an increased risk of coronary artery disease (OR 2.427).
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