Clinical Effects of the Dichloro and Monochlorophenyl Analogues of Diamino Pyrimidine: Antagonists of Folic Acid12

This is the authors' abstract. We don't add key points for this paper.

Hitchings, Elion, Vanderwerff, and Falco (1) demonstrated that certain 2,4-diamino-pyrimidines inhibited the growth of L. casei; this inhibition could be reversed by folic acid and citrovorum factor. The effects of these active pyrimidines are activity is associated with the presence of 2 and 4 amino groups in the pyriniidine nucleus, and a weighty substituent in the 5 position, suggesting a definite similarity in molecular configuration to the folic acid antagonists (Figure FIGURE 1 N AMINOPTERIN Cl NH2 1/ Cl' HN S N CH: 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP)