Why the study?
What clinical covariates affect the change in QTc interval and discontinuation among real-world patients treated with sotalol?
Population
541 patients with a new prescription for sotalol, mean age 64 ± 13 years, 37% women, predominant indication…
Design
Cohort
Follow-up
within 3 days of initiation
Authors
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Risk-stratified QTc monitoring may be warranted with sotalol; leaves open prospective validation of arrhythmia outcomes.
What clinical covariates affect the change in QTc interval and discontinuation among real-world patients treated with sotalol?
In a real-world cohort, sotalol initiation resulted in highly variable QTc prolongation, with multiple clinical factors including female gender, age, and reduced LVEF predicting increased QTc.
Weeke et al. (2013) studied this question.
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