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July 12, 2017Frontiers in PhysiologyOpen Access

Longitudinal Associations of Leptin and Adiponectin with Heart Rate Variability in Children

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Why the study?

Do energy-related biomarkers leptin and adiponectin correlate with heart rate variability in children?

Population

249 healthy Belgian children aged 4.4-11.0 years at baseline, recruited for the longitudinal ChiBS study.

Design

Cohort

Follow-up

2 years

Authors

RWRoos Van De WielleUniversity College GhentNMNathalie MichelsGhent University Hospital

Discussion

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Implication

Sex-specific adipokine-HRV links in children warrant caution in risk interpretation; leaves open prospective validation for early CVD screening.

Structured PICO

Do energy-related biomarkers leptin and adiponectin correlate with heart rate variability in children?

P
Population
249 healthy Belgian children (125 boys, 124 girls) aged 4.4-11.0 years at baseline, recruited for the longitudinal ChiBS study.
O
Outcome
Heart rate variability (HRV) parameters including pNN50, LF, HF, and LF/HF ratio measured in supine position over 10 minutessurrogate

Leptin is associated with a disadvantageous autonomic balance, while adiponectin is associated with an advantageous autonomic balance in girls only, highlighting sex differences in early cardiovascular risk markers.

Limitations

  • Selection bias with more high-educated parents
  • Exclusion of low-quality data and technical problems with measurements reducing sample size
  • LF is not a perfect sympathetic parameter
  • Different leptin analysis kits used at baseline and follow-up

Cite This Study

Wielle et al. (2017) studied this question.

synapsesocial.com/papers/6a73b2899d09e2fbac27a133https://doi.org/10.3389/fphys.2017.00498
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Also Consider

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  1. 1Dysregulation of Autonomic Nervous System in Chagas’ Heart Disease Is Associated with Altered Adipocytokines Levels2015 · 33 citations
  2. 2Adiponectin Concentrations in Sera From Patients With Type 2 Diabetes Are Negatively Associated With Sympathovagal Balance as Evaluated by Power Spectral Analysis of Heart Rate Variation2004 · 52 citations
  3. 3The LF/HF ratio does not accurately measure cardiac sympatho-vagal balance2013 · 1,411 citations
  4. 4The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective2013 · 1,654 citations