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July 14, 2009BloodOpen Access

B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders

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Authors

RWRyan A. WilcoxUniversity of MichiganAFAndrew L. FeldmanToyota Motor Corporation (Switzerland)DWDavid A. WadaUniversity of Utah

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Implication

Laboratory study reveals B7-H1-mediated immune suppression in T-cell non-Hodgkin lymphoma, suggesting targeted inhibition as a potential therapeutic approach.

Key Points

  • To examine the expression and immunosuppressive functional effects of B7-H1 (PD-L1, CD274) within cutaneous and peripheral T-cell non-Hodgkin lymphoma.
  • Evaluated B7-H1 expression across tumor cells and microenvironmental stromal elements, including monocytes and monocyte-derived cells, in cutaneous and peripheral T-cell non-Hodgkin lymphoma.
  • Characterized the functional effects of B7-H1 on T-cell proliferation and the differentiation of FoxP3(+) regulatory T cells.
  • B7-H1 was expressed by malignant T cells, monocytes, and monocyte-derived cells localized within the lymphoma microenvironment.
  • B7-H1 expression significantly inhibited T-cell proliferative responses and promoted the induction of immunosuppressive FoxP3(+) regulatory T cells.

Cite This Study

Wilcox et al. (2009) studied this question.

synapsesocial.com/papers/6a73b396f82dff6409279fdbhttps://doi.org/10.1182/blood-2009-04-216671
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