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September 1, 2023Journal of Pure and Applied MicrobiologyOpen Access

A Retrospective Study to Determine the Genotypic Distribution of Hepatitis-C from a Tertiary Care Hospital in South India

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Authors

BAB AppalarajuMRM. Mohamadiya Rizwana

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Overview

Retrospective study uncovers a predominance of genotype 4 among hepatitis C virus infections in South India, highlighting shifting regional viral epidemiology.

Key Points

  • To determine the genotypic distribution and viral load patterns of hepatitis C virus among clinical patients evaluated at a tertiary care center.
  • Screened patient serum samples for hepatitis C virus antibodies using chemiluminescence immunoassay (CLIA).
  • Performed HCV genotyping via multiplex polymerase chain reaction on CLIA-positive samples and quantified viral loads in a subset (n=81).
  • Identified Genotype 4 as the most common strain (35.71%), followed by Genotype 3 (17.53%), Genotypes 1 and 1b (12.34%), with mixed genotypes 1/1b/4 and 4/5 observed in 0.65% of samples each.
  • Quantified HCV viral load in 61 of 81 tested samples, with loads ranging from 550 to 552,769,250 IU/ml (log 2.74 to log 8.74) and a mean antibody value of 11.51 ± 4.57.

Cite This Study

Appalaraju et al. (2023) studied this question.

synapsesocial.com/papers/6a73bac1dcf9e352178de34ehttps://doi.org/10.22207/jpam.17.3.51
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