Population
Drosophila flight muscle actin (wild type ACT88F and E93K mutant)
Comparison
Addition of tropomyosin and troponin at pCa5 and… vs Wild type actin vs E93K mutant actin; actin…
Design
Preclinical
Authors
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Does not support clinical translation; leaves open whether actin domain-2 charge mutations alter cardiac thin-filament regulation in vivo.
Electrostatic charge on the surface of domain 2 of actin plays a critical role in the steric blocking mechanism of actin filament regulation by tropomyosin.
Bing et al. (1998) studied this question.
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