Population
In vitro motility assay using individual actin-tropomyosin filaments moving over immobilized skeletal muscle…
Comparison
Addition of troponin and varying calcium… vs Baseline state
Design
Preclinical
Authors
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Supports all-or-none thin-filament cooperativity in vitro; leaves open translation to human cardiac function or disease.
Troponin and calcium regulate actin-tropomyosin filaments as a single cooperative unit in an 'all or none' process, recruiting motile filaments.
Fraser et al. (1995) studied this question.
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