What question did this study set out to answer?

To evaluate the clinical significance of a tertiary grade 5 pattern in Gleason score 7 radical prostatectomy specimens and its relationship with pathological stage and biochemical recurrence-free survival.

January 9, 2008The Journal of Urology

Significance of Tertiary Gleason Pattern 5 in Gleason Score 7 Radical Prostatectomy Specimens

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To evaluate the clinical significance of a tertiary grade 5 pattern in Gleason score 7 radical prostatectomy specimens and its relationship with pathological stage and biochemical recurrence-free survival.
Pathologically reexamined radical prostatectomy specimens from 300 patients with Gleason score 7 (3 + 4 or 4 + 3) prostate cancer.
Included 214 eligible patients to evaluate the presence of tertiary grade 5 patterns.
Analyzed associations with pathological stage, adverse histological features, and biochemical recurrence-free survival.
Tumors with tertiary grade 5 patterns were associated with significantly higher pathological stage (p < 0.001) as well as increased seminal vesicle invasion, extraprostatic extension, and lymphovascular invasion (p < 0.05).
Biochemical recurrence-free survival was significantly reduced in patients with tertiary pattern 5 compared to those without (54 months vs 121 months; p = 0.0005).
Preoperative prostate-specific antigen, lymphovascular invasion, and positive surgical margin status independently predicted prostate-specific antigen recurrence on multivariate analysis.

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Implication

Retrospective cohort study reveals tertiary Gleason pattern 5 worsens recurrence-free survival in Gleason 7 prostate cancer, indicating more aggressive disease behavior.

Cite This Study

Whittemore et al. (2008) studied this question.

synapsesocial.com/papers/6a73bff5c1c8cbdb1d8de4c5 https://doi.org/10.1016/j.juro.2007.09.085

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Implication

Retrospective cohort study reveals tertiary Gleason pattern 5 worsens recurrence-free survival in Gleason 7 prostate cancer, indicating more aggressive disease behavior.

Significance of Tertiary Gleason Pattern 5 in Gleason Score 7 Radical Prostatectomy Specimens

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Discussion

Implication

Cite This Study

Significance of Tertiary Gleason Pattern 5 in Gleason Score 7 Radical Prostatectomy Specimens

Key Points

Discussion

Implication

Cite This Study

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