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December 1, 2004Journal of Bone and Mineral Research

Decreased BMD and Limb Deformities in Mice Carrying Mutations in Both Lrp5 and Lrp6

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Authors

SHSheri L. HolmenUniversity of UtahTGTroy A. GiambernardiUniversity of Southern CaliforniaCZCassandra R. ZylstraVan Andel Institute

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Holmen et al. (2004) studied this question.

synapsesocial.com/papers/6a73c01ac973d0bd5a69f09bhttps://doi.org/10.1359/jbmr.040907
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1High Bone Mass in Mice Expressing a Mutant LRP5 Gene2003 · 500 citations
  2. 2Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor2002 · 1,094 citations
  3. 3Isolation and Characterization ofposMutants Defective in Correct Positioning of Septum in Schizosaccharomyces pombe1996 · 182 citations
  4. 4Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion2002 · 399 citations