Pushing the envelope: The calculated free energy profile for the insertion of H-ras anchor into a dimyristoyl-sn-glycero-3-phosphocholine bilayer shows a steeply downhill profile. The insertion into the hydrocarbon core of the ras lipids and the interfacial localization of the backbone together account for a binding free energy of about −30 kcal mol−1.
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Gorfe et al. (2007) studied this question.
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