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October 1, 1996Journal of Bone and Mineral Research

Tartrate-resistant acid phosphatase from human bone: Purification and development of an immunoassay

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Authors

JHJussi M. HalleenDominion (United States)THTeuvo A. HentunenUniversity of TurkuJHJukka HellmanÅbo Akademi University

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Implication

This randomized trial measures serum TRAP concentrations in children and postmenopausal women, suggesting hormone influence on levels.

Key Points

  • The aim was to purify tartrate-resistant acid phosphatase from human bone and develop an immunoassay to measure serum concentrations.
  • Purification of TRAP from human bone with a 20,000-fold enrichment.
  • Development of a polyclonal antiserum in mice and a competitive fluorescence immunoassay.
  • Comparison of serum TRAP concentrations across different demographic groups.
  • Children exhibited higher serum TRAP levels compared to adults.
  • Postmenopausal women had higher serum TRAP than premenopausal women.
  • Postmenopausal women on estrogen replacement therapy had lower TRAP levels than those not on therapy.

Cite This Study

Halleen et al. (1996) studied this question.

synapsesocial.com/papers/6a73c124d3d4e530dbfb7dddhttps://doi.org/10.1002/jbmr.5650111011
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