lndium-111 Leukocyte Uptake in Neoplasms

This is the authors' abstract. We don't add key points for this paper.

Uptake of In-111 leukocytes by tumors may lead to a false diagnosis of abscess. Differentiation of tumor from abscess is an especially important problem in the brain. A patient with a metastatic brain lesion that showed In-111 WBC uptake was studied. Subsequently, 19 tumor sites were studied in 16 patients who had variety of neoplasms. In nine sites, histologic examination of biopsy or autopsy material showed granulocytic, lymphocytic, or macrophagic infiltration, and six of these had In-111 leukocyte uptake. Three sites had brain metastases, and uptake occurred variably in a variety of other tumors. Uptake of In-111 leukocytes by tumors must be recognized as a diagnostic hazard using this method for detection of suspected abscesses, which may be especially confusing in a patient with cancer.