Population
3-, 10-, and 17-day-old embryonic chick ventricular heart cells
Comparison
Whole-cell voltage-clamp experiments vs Comparison across different developmental age…
Design
Preclinical
Authors
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Should not inform clinical decisions; leaves open whether developmental Na current shifts influence human fetal arrhythmia risk.
This preclinical study demonstrates that during embryonic heart development, cardiac sodium current density increases significantly while steady-state window current conductance decreases due to a negative shift in inactivation voltage dependence.
Sada et al. (1995) studied this question.
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