Population
Neonatal (1-2-day-old) and adult rat ventricular cardiac myocytes
Comparison
Phenytoin (40 microM) vs Adult rat ventricular cardiac myocytes compared…
Design
Preclinical
Authors
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May indicate greater neonatal phenytoin sensitivity; hypothesis-generating for age-specific sodium channel pharmacology in humans.
There are significant developmental changes in the sodium channel blocking effects of class I antiarrhythmic drugs like phenytoin in rat cardiac tissue, with greater tonic and use-dependent block observed in neonatal myocytes.
Xu et al. (1991) studied this question.
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