What question did this study set out to answer?

To determine whether the glycation gap predicts the progression of nephropathy in patients with type 2 diabetes independently of HbA1c and fructosamine.

December 8, 2010Clinical ChemistryOpen Access

Progression of Nephropathy in Type 2 Diabetes: The Glycation Gap Is a Significant Predictor after Adjustment for Glycohemoglobin (Hb A1c)

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To determine whether the glycation gap predicts the progression of nephropathy in patients with type 2 diabetes independently of HbA1c and fructosamine.
Conducted a retrospective cohort study of 2314 patients with type 2 diabetes followed for an average of 6.5 (SD 4.2) years.
Calculated raw glycation gap values across repeated visits using longitudinal regression of HbA1c on serum fructosamine, defining patient-level mean glycation gap.
Categorized patients into low-, medium-, and high-gap tertiles and assessed nephropathy progression with Cox regression adjusting for age, sex, diabetes duration, baseline nephropathy, treatment, baseline/mean HbA1c, and fructosamine.
Patients in the high-glycation gap tertile had a 2.5-fold increased risk of nephropathy progression compared to the low-gap tertile (P < 0.0001).
Patients in the medium-glycation gap tertile demonstrated a 1.6-fold increased risk of nephropathy progression relative to the low-gap tertile (P = 0.001).

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Implication

Cohort study reveals an elevated glycation gap independently predicts nephropathy progression in type 2 diabetes, suggesting nonglycemic factors influence renal complication risk.

Cite This Study

Rodrı́guez-Segade et al. (2010) studied this question.

synapsesocial.com/papers/6a73c9471aa2fc9e78fb7274 https://doi.org/10.1373/clinchem.2010.144949

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Implication

Cohort study reveals an elevated glycation gap independently predicts nephropathy progression in type 2 diabetes, suggesting nonglycemic factors influence renal complication risk.

Progression of Nephropathy in Type 2 Diabetes: The Glycation Gap Is a Significant Predictor after Adjustment for Glycohemoglobin (Hb A1c)

Key Points

Discussion

Implication

Cite This Study

Progression of Nephropathy in Type 2 Diabetes: The Glycation Gap Is a Significant Predictor after Adjustment for Glycohemoglobin (Hb A1c)

Key Points

Discussion

Implication

Cite This Study

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