Human Papillomavirus-11 DNA in a Patient with Chronic Laryngotracheobronchial Papillomatosis and Metastatic Squamous-Cell Carcinoma of the Lung

LARYNGEAL papillomas are benign epithelial tumors that primarily involve the larynx and epiglottis but may extend into the trachea and the bronchi. The development of invasive squamous-cell carcinoma in association with laryngeal papillomatosis is rare and occurs almost exclusively in patients who have had radiation therapy.1 , 2 Laryngeal papillomas are caused by specific human papillomaviruses (HPVs), which have a specific tropism for squamous epithelial cells and which can induce cellular proliferation or dysplasia.More than 46 distinct types of HPVs have been identified, and two of them have been specifically associated with laryngeal papillomas. These are HPV-11, which was originally detected . . .