Ischemic stroke in patients with POEMS syndrome is frequently associated with cerebral vasculopathy and predicts a poor outcome with high mortality within two years.
Answers are grounded in this paper and cite their sources.
POEMS syndrome may underlie atypical ischemic stroke; this case report leaves open prevalence and causality.
// Fang-Wang Fu 1,* , Jie Rao 2,* , Yuan-Yuan Zheng 1 , Hui-Lin Wang 1 , Jian-Guang Yang 1 , and Guo-Qing Zheng 1 1 Department of Neurology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou city, China 2 Department of Neurology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Central Hospital, Lishui City, China * Co-first author Correspondence to: Guo-Qing Zheng, email: // Keywords : POEMS syndrome, ischemic stroke, vasculopathy, vascular endothelial growth factor, vessel wall imaging Received : March 29, 2017 Accepted : June 28, 2017 Published : August 10, 2017 Abstract Background: POEMS syndrome is a rare multi-systemic disease characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes. Arterial or venous thrombosis is a less-common complication of POEMS syndrome. Ischemic stroke has also been reported sporadically. However, the association between POEMS syndrome and ischemic stroke has not been entirely understood. Methods: A case of ischemic stroke caused by cerebral vasculitis in a patient with POEMS syndrome was presented. Then a comprehensive review and analysis of the literature were performed. Results: A total of 28 patients were identified. The common clinical manifestations of POEMS syndrome were rather non-specific in patients with ischemic stroke compared with those of patients without ischemic stroke. Twenty patients were found with multiple ischemic lesions (71.5%). In the 25 patients who had undergone the evaluation of cerebral arteries, nineteen patients (76.0%) were found with cerebral vasculopathy. Twelve patients (48.0%) had more than one cerebral artery involved. Ischemic events were documented in 8 patients even when they were undergoing all the therapy for ischemic stroke. Ten (55.6%) of the 18 patients who had survival data died within two years after stroke events. Conclusion: Comprehensive analysis of literature revealed several trends in patients with ischemic stroke and POEMS syndrome including a low survival rate and a preponderance of cerebral vasculopathy and multiple cerebral arteries affected. Ischemic stroke may be a poor outcome predictor in patients with POEMS syndrome. Further researches focusing on a larger cohort may help in better characterizing and treating this rare complication of POEMS syndrome.
No takes yet. Share an insight, caveat, or question.
Fu et al. (2017) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: