Cerebral infarction in POEMS syndrome
Key result
Elevated platelet count and bone marrow plasmacytosis were associated with an increased risk of cerebral infarction in patients with POEMS syndrome, who demonstrated a 5-year stroke risk of 13.4%.
Why the study?
What are the incidence and risk factors for cerebral infarction in patients with POEMS syndrome?
Population
Patients with POEMS syndrome from the Mayo Clinic dysproteinemia database
Design
Cohort
Authors
Discussion
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Member takes
Implication
May support platelet monitoring in POEMS; hypothesis-generating for prospective prevention trials.
Study Design
Type
Observational (n=90)
Structured PICO
What are the incidence and risk factors for cerebral infarction in patients with POEMS syndrome?
P
Population
90 patients with POEMS syndrome from the Mayo Clinic dysproteinemia database, evaluated retrospectively for predictors and incidence of cerebral infarction.
C
Comparator
Patients with POEMS syndrome without cerebral infarction
O
Outcome
Incidence and predictors of cerebral infarctionhard clinical
Patients with POEMS syndrome have a 13.4% 5-year risk of cerebral infarction, driven by hematologic abnormalities like thrombocytosis and bone marrow plasmacytosis.
Cite This Study
Dupont et al. (2009) conducted an observational in POEMS syndrome (n=90). Elevated platelet count and bone marrow plasmacytosis vs. Absence of these hematologic abnormalities was evaluated on Cerebral infarction (95% CI 5.4-17.9). Elevated platelet count and bone marrow plasmacytosis were associated with an increased risk of cerebral infarction in patients with POEMS syndrome, who demonstrated a 5-year stroke risk of 13.4%.