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January 1, 2017Oxidative Medicine and Cellular LongevityOpen Access

Salvianolic Acid Exerts Cardioprotection through Promoting Angiogenesis in Animal Models of Acute Myocardial Infarction: Preclinical Evidence

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Why the study?

Does salvianolic acid improve angiogenesis and reduce infarct size in animal models of myocardial infarction?

Population

14 studies involving 226 animals with experimental myocardial infarction

Comparison

Salvianolic acid vs Control group

Design

Meta-analysis

Authors

LYLong-jie YuWenzhou Medical UniversityKZKejian ZhangCincinnati Children's Hospital Medical CenterJZJiazhen ZhuNanjing University

Discussion

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Implication

Salvianolic acid may promote post-MI angiogenesis in animals; leaves open clinical translation and requires human trials.

Structured PICO

Does salvianolic acid improve angiogenesis and reduce infarct size in animal models of myocardial infarction?

P
Population
14 studies involving 226 animals with experimental myocardial infarction
I
Intervention
Salvianolic acid (including salvianolic acid A and B)
C
Comparator
Control group
O
Outcome
Vascular endothelium growth factor (VEGF), blood vessel density (BVD), and myocardial infarct sizesurrogate

Salvianolic acid exerts cardioprotective effects by promoting angiogenesis and reducing infarct size in animal models of myocardial infarction.

Cite This Study

Yu et al. (2017) studied this question.

synapsesocial.com/papers/6a73d5f8c1c8cbdb1d8de7a8https://doi.org/10.1155/2017/8192383
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Also Consider

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  2. 2Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis2013 · 56 citations
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