Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 31, 2002Hypertension

Angiotensin Blockade Prevents Type 2 Diabetes by Formation of Fat Cells

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does blockade of the renin-angiotensin system prevent type 2 diabetes by promoting the recruitment and differentiation of adipocytes?

Design

Other

Authors

ASArya M. SharmaJJJürgen JankeKGKerstin Gorzelniak

Discussion

Loading...

Member takes

Overview

Hypothesis-generating for RAS blockade via adipocyte differentiation; leaves open clinical diabetes prevention pending trials.

Key Points

  • To determine the biological mechanism by which renin-angiotensin system blockade prevents the development of type 2 diabetes.
  • Evaluation of mechanistic interactions between angiotensin II signaling via the angiotensin type 1 receptor and human adipocyte differentiation.
  • Analysis of the relationship between adipose tissue expression of angiotensin II-forming enzymes and systemic insulin sensitivity.
  • Angiotensin II markedly inhibits the adipogenic differentiation of human adipocytes via angiotensin type 1 receptors, with adipose angiotensin II-forming enzyme levels inversely correlating with insulin sensitivity.
  • Pharmacological blockade of the renin-angiotensin system promotes adipocyte recruitment and differentiation, preventing ectopic lipid deposition in muscle, liver, and pancreas to improve insulin sensitivity.

Structured PICO

Does blockade of the renin-angiotensin system prevent type 2 diabetes by promoting the recruitment and differentiation of adipocytes?

I
Intervention
Blockade of the renin-angiotensin system (ACE inhibitors or angiotensin type 1 receptor blockers)
O
Outcome
Prevention of type 2 diabetes

The paper proposes a novel mechanistic hypothesis explaining how renin-angiotensin system blockade may prevent type 2 diabetes through enhanced adipocyte differentiation and reduced ectopic lipid deposition.

Cite This Study

Sharma et al. (2002) studied this question.

synapsesocial.com/papers/6a73d65746cd4472af69f26ahttps://doi.org/10.1161/01.hyp.0000036448.44066.53
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hormonal regulation of the human adipose-tissue renin–angiotensin system: relationship to obesity and hypertension2002 · 210 citations
  2. 2Ramipril and the Development of Diabetes2001 · 547 citations
  3. 3Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol2002 · 5,433 citations
  4. 4Angiotensin II as a Trophic Factor of White Adipose Tissue: Stimulation of Adipose Cell Formation**This work was supported by a grant from the Fondation pour la Recherche Medicale.2001 · 128 citations
  5. 5Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice2000 · 683 citations