February 21, 2008Journal of Cardiovascular Pharmacology and TherapeuticsOpen Access

Cardiac Oxidative Stress Is Elevated at the Onset of Dilated Cardiomyopathy in Streptozotocin-Diabetic Rats

View Full Paper

Ask AI

Bookmark

Why the study?

Does STZ-induced diabetes alter cardiac oxidative stress and function in rats?

Population

Streptozotocin (STZ)-diabetic rats

Comparison

STZ-induced diabetes (disease model) vs Control (CT) rats

Design

Preclinical

Authors

MCMaría J. CrespoUniversity of Puerto Rico System JZJoaquin ZalacaínGrady Memorial Hospital DDDonald DunbarUniversity of Minnesota

Discussion

Member takes

Implication

Does not support clinical translation; hypothesis-generating for NOS-targeted interventions in diabetic cardiomyopathy.

Structured PICO

Does STZ-induced diabetes alter cardiac oxidative stress and function in rats?

Population

Streptozotocin (STZ)-diabetic rats

Intervention

STZ-induced diabetes (disease model)

Comparator

Control (CT) rats

Outcome

Cardiac function (stroke volume, cardiac output, left ventricular ejection fraction, left ventricular end-systolic volume) and oxidative stress markers (eNOS, iNOS, superoxide production, cardiac NOS activity)surrogate

Increased oxidative stress and activation of cardiac eNOS and iNOS are associated with decreased cardiac function at the onset of dilated cardiomyopathy in STZ-diabetic rats.

Cite This Study

Crespo et al. (2008) studied this question.

synapsesocial.com/papers/6a73d7ffd0d1650e4d69f4bd https://doi.org/10.1177/1074248407307854

View Full Paper

Ask AI

Bookmark

Cardiac Oxidative Stress Is Elevated at the Onset of Dilated Cardiomyopathy in Streptozotocin-Diabetic Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiac Oxidative Stress Is Elevated at the Onset of Dilated Cardiomyopathy in Streptozotocin-Diabetic Rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider