Why the study?
Coxsackievirus A16 is a major etiological agent of hand, foot and mouth disease, but its molecular epidemiology and evolutionary characteristics required investigation.
The study demonstrates that CVA16 strains circulating in Beijing from 2010 to 2019 predominantly belonged to clade B1b and evolved at a fast rate, highlighting the need for ongoing molecular surveillance for HFMD prevention.
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Fast-evolving B1b CVA16 dominant in Beijing HFMD; leaves open need for updated surveillance and vaccine matching.
Hu et al. (2021) studied this question.
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