July 13, 2022HypertensionOpen Access

Males had faster rates of increase in SBP before puberty leading to 10.19 mm Hg (95% CI, 6.80-13.57) higher mean SBP at puberty, which remained similar at 24 years (mean difference, 11.43 mm Hg [95% CI, 7.22-15.63]).

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Why the study?

Sex differences in systolic blood pressure emerge during adolescence, but the role of puberty is not well understood.

Does puberty timing and sex influence systolic blood pressure trajectories from childhood to early adulthood?

Population

4062 participants in a contemporary birth cohort study

Comparison

SBP trajectories before and after puberty and by puberty timing in females vs males

Design

Prospective cohort study

Follow-up

From age 3 to 24 years

Authors

KOKate O’Neill JBJoshua A. Bell GSGeorge Davey Smith

Discussion

Member takes

Overview

Puberty timing may shape sex-specific SBP trajectories; leaves open causal links to adult hypertension and need for prospective trials.

Structured PICO

Does puberty timing and sex influence systolic blood pressure trajectories from childhood to early adulthood?

Population

4,062 participants from a contemporary birth cohort study, followed from age 3 to 24 years.

Intervention

Puberty timing (age at peak height velocity) and sex

Comparator

Between sexes (males vs females) and different puberty timings

Outcome

Systolic blood pressure (SBP) trajectories before and after puberty and at age 24surrogate

The higher systolic blood pressure observed in males compared to females in early adulthood is largely accrued before puberty, suggesting interventions targeting puberty timing are unlikely to influence early adulthood SBP.

Cite This Study

O’Neill et al. (2022) studied this question.

synapsesocial.com/papers/6a73dc710375516f85f15fff https://doi.org/10.1161/hypertensionaha.121.18531

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July 13, 2022HypertensionOpen Access

Males had faster rates of increase in SBP before puberty leading to 10.19 mm Hg (95% CI, 6.80-13.57) higher mean SBP at puberty, which remained similar at 24 years (mean difference, 11.43 mm Hg [95% CI, 7.22-15.63]).

View Full Paper

Ask AI

Bookmark

Why the study?

Sex differences in systolic blood pressure emerge during adolescence, but the role of puberty is not well understood.

Does puberty timing and sex influence systolic blood pressure trajectories from childhood to early adulthood?

Population

4062 participants in a contemporary birth cohort study

Comparison

SBP trajectories before and after puberty and by puberty timing in females vs males

Design

Prospective cohort study

Follow-up

From age 3 to 24 years

Authors

KOKate O’Neill JBJoshua A. Bell GSGeorge Davey Smith

Discussion

Member takes

Overview

Puberty timing may shape sex-specific SBP trajectories; leaves open causal links to adult hypertension and need for prospective trials.

Structured PICO

Does puberty timing and sex influence systolic blood pressure trajectories from childhood to early adulthood?

Population

4,062 participants from a contemporary birth cohort study, followed from age 3 to 24 years.

Intervention

Puberty timing (age at peak height velocity) and sex

Comparator

Between sexes (males vs females) and different puberty timings

Outcome

Systolic blood pressure (SBP) trajectories before and after puberty and at age 24surrogate

Cite This Study

O’Neill et al. (2022) studied this question.

synapsesocial.com/papers/6a73dc710375516f85f15fff https://doi.org/10.1161/hypertensionaha.121.18531

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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