Why the study?
Do selective serotonin reuptake inhibitors reduce platelet serotonin levels and aggregation in patients with depression?
Population
41 subjects including 13 untreated depressed patients, 14 SSRI-treated depressed patients, and 14 normal…
Comparison
Selective serotonin reuptake inhibitors (SSRIs) vs Untreated depressed patients and normal control…
Design
Cross-sectional
Authors
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SSRIs may reduce platelet serotonin and aggregation in depression; hypothesis-generating for cardiovascular benefits, should not yet change practice.
Do selective serotonin reuptake inhibitors reduce platelet serotonin levels and aggregation in patients with depression?
SSRIs significantly reduce platelet serotonin levels and ADP-induced platelet aggregation, providing a potential mechanistic explanation for their cardiovascular benefits in depressed patients.
Pittendreigh et al. (2003) studied this question.
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