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August 12, 2012AJP Heart and Circulatory Physiology

Hypothermia-induced spatially discordant action potential duration alternans and arrhythmogenesis in nonhibernating versus hibernating mammals

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Population

Langendorff-perfused hearts of winter hibernating, interbout arousal, and summer active ground squirrels and…

Comparison

Hypothermia vs Baseline temperature and comparison between…

Design

Preclinical

Authors

YEYu. V. EgorovAGAlexey V. GlukhovIEIgor R. Efimov

Discussion

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Overview

Hibernator resistance to hypothermia-induced VF is hypothesis-generating; leaves open mechanistic translation to human arrhythmia prevention.

Structured PICO

P
Population
Langendorff-perfused hearts of winter hibernating (WH, n = 13), interbout arousal (IBA; n = 4), and summer active (SA, n = 6) ground squirrels (Spermophilus undulatus) and rabbits (n = 10)
I
Intervention
Hypothermia (temperature reduction from 37°C to 17°C)
C
Comparator
Baseline temperature (37°C) and comparison between species (rabbits vs. ground squirrels)
O
Outcome
Action potential duration (APD) and conduction velocity (CV) dynamic restitution and alternans, and onset of ventricular fibrillationsurrogate

Hibernating species resist hypothermia-induced ventricular fibrillation through dynamically stable conduction and low dispersion of repolarization, which prevents spatially discordant alternans.

Cite This Study

Egorov et al. (2012) studied this question.

synapsesocial.com/papers/6a73dcdf8055c84dbef16136https://doi.org/10.1152/ajpheart.00786.2011
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Electrical and mechanical alternans in canine myocardium in vivo. Dependence on intracellular calcium cycling.1993 · 89 citations
  2. 2Cellular uncoupling can unmask dispersion of action potential duration in ventricular myocardium. A computer modeling study.1989 · 171 citations
  3. 3Therapeutic Hypothermia (30.DEG.C) Enhances Arrhythmogenic Substrates, Including Spatially Discordant Alternans, and Facilitates Pacing-Induced Ventricular Fibrillation in Isolated Rabbit Hearts2009 · 34 citations
  4. 4Spatially discordant alternans in cardiomyocyte monolayers2008 · 47 citations
  5. 5Role of Calcium Cycling Versus Restitution in the Mechanism of Repolarization Alternans2004 · 292 citations