What question did this study set out to answer?

To determine whether autonomic modulation of the heart changes during low-intensity lower body negative pressure before any alteration in mean heart rate occurs.

December 11, 2001CirculationOpen Access

Sequential Modulation of Cardiac Autonomic Control Induced by Cardiopulmonary and Arterial Baroreflex Mechanisms

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Why the study?

Does nonhypotensive lower body negative pressure alter cardiac autonomic control in healthy volunteers?

Population

10 healthy volunteers

Comparison

Increasing levels of lower body negative… vs Baseline conditions

Design

Other

Authors

RFRaffaello FurlanGeneral Cardiology GJGiris JacobGeneral Cardiology LPLaura PalazzoloNew York University

Discussion

Member takes

Implication

Nonhypotensive LBNP may elicit early sympathetic activation in healthy subjects; hypothesis-generating for autonomic monitoring before overt hemodynamic change.

Key Points

To determine whether autonomic modulation of the heart changes during low-intensity lower body negative pressure before any alteration in mean heart rate occurs.
Evaluated 10 healthy volunteers during incremental lower body negative pressure up to -40 mm Hg.
Continuously recorded ECG, finger blood pressure, respiration, central venous pressure, and plasma catecholamines.
Analyzed autonomic cardiac regulation and arterial baroreflex sensitivity using spectral analysis of R-R interval variability and spontaneous sequence techniques.
Central venous pressure decreased significantly at -10 mm Hg, normalized low-frequency R-R interval variability increased at -15 mm Hg, and R-R interval shortened at -20 mm Hg.
Plasma norepinephrine levels rose and baroreflex sensitivity indexes decreased at -20 to -30 mm Hg, whereas systolic arterial pressure dropped only at -40 mm Hg.

Structured PICO

Does nonhypotensive lower body negative pressure alter cardiac autonomic control in healthy volunteers?

Population

10 healthy volunteers

Intervention

Increasing levels of lower body negative pressure (LBNP) up to -40 mm Hg

Comparator

Baseline conditions

Outcome

Changes in the spontaneous variability of R-R interval, respiration, systolic arterial pressure (SAP), and central venous pressure (CVP) and in the gain (alpha(LF)) of arterial baroreflex control of heart ratesurrogate

Nonhypotensive lower body negative pressure elicits a reflex increase in cardiac sympathetic modulation that precedes hemodynamic changes.

Cite This Study

Furlan et al. (2001) studied this question.

synapsesocial.com/papers/6a73dce28055c84dbef1613d https://doi.org/10.1161/hc4901.100360

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Implication

Nonhypotensive LBNP may elicit early sympathetic activation in healthy subjects; hypothesis-generating for autonomic monitoring before overt hemodynamic change.

Sequential Modulation of Cardiac Autonomic Control Induced by Cardiopulmonary and Arterial Baroreflex Mechanisms

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Sequential Modulation of Cardiac Autonomic Control Induced by Cardiopulmonary and Arterial Baroreflex Mechanisms

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider