Identification of peptide binding residues in the extracellular domains of the AT1 receptor.

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Population

AT1 receptor mutants (in vitro model)

Design

Preclinical

Authors

Discussion

Does not support changes to AT1 antagonist use; extends peptide-binding epitope mapping in animal models.

Population

AT1 receptor mutants (in vitro model)

Intervention

Systematic mutational analysis (conservative segment exchange and point mutagenesis of evolutionarily conserved residues)

Outcome

Binding affinity for peptide agonist angiotensin II (AII) and peptide antagonist [Sar1,Leu8]AIIsurrogate

Important epitopes involved in angiotensin II binding are located around the top of transmembrane segments I, II, and VII of the AT1 receptor.

Hjorth et al. (1994) studied this question.

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