Why the study?
Enabling large in silico trials and personalized model predictions on clinical timescales requires cardiac models that can be constructed quickly and reproducibly at scale.
Population
1000 biatrial bilayer and volumetric models derived from CT data, plus models from MRI and electroanatomical mapping
Comparison
Effects of fibres, fibrosis, and bilayer versus volumetric model representation on fibrillatory dynamics
Design
In silico computational modelling study
Authors
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May accelerate scalable atrial in silico trials; leaves open clinical validation before personalized use.
The development of an open-source pipeline for generating atrial models enables large-scale in silico clinical trials and demonstrates that fibrotic remodeling stabilizes re-entries across different model representations.
Roney et al. (2023) studied this question.
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