Association of ITGA2 Dual Site Variants with Recurrent Ischemic Events in Patients Undergoing Stenting for Symptomatic Intracranial Atherosclerotic Stenosis

Objective : We aimed to investigate the relationship between gene polymorphisms and the occurrence of adverse clinical events following dual antiplatelet therapy in Patients with Symptomatic Intracranial Atherosclerotic Stenosis. Methods : A total of 195 patients were enrolled, categorized into 32 cases (those with clinical adverse events) and 163 controls (without events). Genotyping of 20 SNPs from 17 genes was executed. Statistical analyses (Fisher’s exact test, logistic regression) were applied to determine associations. Results : The ITGA2 rs1126643 (C807T) and rs1062535 (G873A) polymorphisms were significantly correlated with adverse clinical events. Specifically, the mutant frequency of allele C (ITGA2 rs1126643) and allele G (ITGA2 rs1062535) was significantly higher in cases compared to controls (OR = 2.97, 95%CI = 1.702-5.172, P = 0.0001; OR = 3.27, 95%CI = 1.762-6.066, P = 0.0002, respectively). Other genotypes showed no significant differences between the groups. Conclusion : The ITGA2 C807T and G873A polymorphisms may elevate the risk of vascular events in Chinese patients. Detecting these polymorphisms may be valuable in identifying patients at risk of recurrent ischemic events.