Why the study?
Venous thromboembolism has increasing pediatric significance, but recommendations have low evidence due to a lack of well-designed clinical trials and reliance on adult extrapolations.
This review highlights the current guidelines for managing pediatric VTE, noting that recommendations are largely extrapolated from adult data due to a lack of pediatric trials.
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Cautious extrapolation from adult VTE guidelines advised in children; leaves open need for dedicated pediatric trials to inform recommendations.
Bosch et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: