Combination chemotherapy for advanced breast cancer utilizing vincristine, adriamycin, and cyclophosphamide (VAC)

32 patients with advanced breast cancer, mean age 57 years (range 30-79), 18 postmenopausal, no prior chemotherapy, 15 with prior endocrine treatment.

Combination chemotherapy: vincristine (1 mg/m2 IV day 1, max 2 mg), adriamycin (40 mg/m2 IV day 1), and cyclophosphamide (200 mg/m2 oral days 3-6), repeated at 21-28-day intervals.

Objective responsesurrogate