Troponin I and T in relation to cardiac injury detected with electrocardiography in a population-based cohort - The Maastricht Study

Figure 1. Correlation between natural log transformed hs-cTnI and natural log transformed hs-cTnT (β = 0.465, 95% CI 0.442–0.488, p < 0.001, R2 = 0.343). Abbreviations: hs-cTnI, high-sensitivity cardiac troponin I; hs-cTnT, high-sensitivity cardiac troponin T; ln, natural log transformed.

Figure 2. Prevalence of ECG changes indicative of cardiac abnormalities per hs-cTnI quartile, stratified by sex (women; panel A: men; panel B). Abbreviations: ECG, electrocardiographic; hs-cTnI, high-sensitivity cardiac troponin I.

Figure 3. Associations between combined hs-cTn categories and ECG changes indicative of cardiac abnormalities. Definitions of “low” and “high” hs-cTn categories were based on the sex-specific 75th percentiles of hs-cTnI and hs-cTnT (hs-cTnI, women: 2.20 ng/L; hs-cTnI, men: 3.70 ng/L; hs-cTnT, women: 5.55 ng/L; hs-cTnT, men: 9.36 ng/L). Category “low” included participants with hs-cTn levels <the sex-specific 75th percentile and category “high” included participants ≥the sex-specific 75th percentile. Model was adjusted for sex, age, glucose metabolism status, eGFR, smoking behavior, total-to-HDL cholesterol ratio, triglyceride levels, lipid-modifying medication, office systolic blood pressure, antihypertensive medication, waist-to-hip ratio, alcohol consumption and educational level. Abbreviations: ECG, electrocardiographic; eGFR, estimated Glomerular Filtration Rate; HDL, high-density lipoprotein; hs-cTnI, high-sensitivity cardiac troponin I; hs-cTnT, high-sensitivity cardiac troponin T.

Figure 4. ECG changes indicative of cardiac abnormalities categorized according to Whitehall criteria into “probable”, “possible” and “unlikely”. Abbreviations: ECG, electrocardiography; MC, Minnesota Coding.