Why the study?
How does the formation of bile acids differ among patients with different types of hyperlipoproteinemia compared to healthy subjects?
How does the formation of bile acids differ among patients with different types of hyperlipoproteinemia compared to healthy subjects?
Bile acid formation and pool size vary significantly by hyperlipoproteinemia type, being subnormal in type II and elevated in types IV and V.
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Bile acid differences by hyperlipoproteinemia type should not yet change practice; leaves open phenotype-specific therapeutic targeting.
Abstract. 14 C‐cholic and 3 H‐chenodeoxycholic acid were administered orally to patients who were given a standardized diet of the regular type. The total formation of bile acids and the combined cholic and chenodeoxycholic pool in 8 patients with hyper‐β‐lipoproteinaemia (hyperlipoproteinaemia type II) were significantly lower than those recorded for 10 patients with hyperpre‐β‐lipoproteinaemia (hyperlipoproteinaemia type IV) and for 3 patients with combined hyperpre‐β‐lipoproteineamia and hyperchylemicronaemia (hyperlipoproteinaemia type V). These differences were exclusively related to variations of the pool size and turnover of cholic acid. — When compared to a younger group of healthy subjects with a somewhat higher caloric intake, the formation of cholic acid was subnormal in type II and markedly elevated in type TV and V.
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Einarsson et al. (1972) studied this question.
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