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January 1, 1960Circulation Research

Left Ventricle as a Mixing Chamber

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Population

Exposed canine heart model

Design

Preclinical

Authors

HIHiroshi IrisawaDokkyo Medical UniversityMWMichael F. WilsonWest Virginia UniversityRRRobert F. RushmerUniversity of Washington

Discussion

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Implication

May invalidate single-cycle indicator dilution for LV volumes; leaves open mixing assumptions at physiologic heart rates in animal models.

Structured PICO

P
Population
Exposed canine heart model
I
Intervention
Injection of saline (indicator dilution technique)
O
Outcome
Completeness of mixing of blood and injected saline during one cardiac cyclesurrogate

The assumption of complete mixing of blood and indicator in the left ventricle during a single cycle is flawed, potentially causing errors in ventricular volume estimation using indicator dilution techniques.

Cite This Study

Irisawa et al. (1960) studied this question.

synapsesocial.com/papers/6a73ea6bc973d0bd5a69f9dchttps://doi.org/10.1161/01.res.8.1.183
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ventricular Nonmixing as a Source of Error in the Estimation of Ventricular Volume by the Indicator-Dilution Technic1960 · 69 citations
  2. 2Estimation of the Residual Volume of the Ventricle of the Dog's Heart by Two Indicator Dilution Technics1956 · 147 citations
  3. 3Thermal dilution assessment of proximal aortic and left ventricular mixing chambers in dogs1986
  4. 4Mixing in the right ventricle and pulmonary artery in man: evaluation of ventricular volume measurements from indicator washout curves1968 · 28 citations
  5. 5Overestimation of Left Ventricular Volume by the Indicator Dilution Technique1966 · 32 citations