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September 1, 1960Circulation ResearchOpen Access

Ventricular Nonmixing as a Source of Error in the Estimation of Ventricular Volume by the Indicator-Dilution Technic

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Population

Anesthetized dogs

Design

Preclinical

Authors

HSH.J.C. SwanAustralian Regenerative Medicine InstituteWBWalter BeckUniversity of Northern Iowa

Discussion

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Implication

Incomplete mixing precludes reliable ventricular volume quantitation by simple dilution formulas; leaves open refined techniques for cardiac research.

Structured PICO

P
Population
Anesthetized dogs
I
Intervention
Indicator-dilution technique and cineangiograms
O
Outcome
Estimation of end-diastolic, end-systolic, and stroke volumes for the left ventriclesurrogate

Incomplete mixing of left atrial blood with residual ventricular volume introduces significant error in estimating ventricular volumes using the indicator-dilution technique.

Cite This Study

Swan et al. (1960) studied this question.

synapsesocial.com/papers/6a73ea6bc973d0bd5a69f9dbhttps://doi.org/10.1161/01.res.8.5.989
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Use of Biplane Cinefluorography for Measurement of Ventricular Volume1958 · 322 citations
  2. 2Estimation of the Residual Volume of the Ventricle of the Dog's Heart by Two Indicator Dilution Technics1956 · 147 citations
  3. 3A Figure of Merit For Catheter Sampling Systems1959 · 35 citations
  4. 4Dynamic Response Characteristics of Systems for Continuous Recording of Concentration Changes in a Flowing Liquid (for Example, Indicator-Dilution Curves)1957 · 67 citations