What question did this study set out to answer?

To compare left ventricular volume, stroke volume, and ejection fraction measurements obtained by fiberoptic indicator-dilution against standard angiocardiography in vivo.

April 1, 1968CirculationOpen Access

The In Vivo Determination of Left Ventricular Volume

View Full Paper

Ask AI

Bookmark

Why the study?

Does the fiberoptic indicator-dilution technique provide comparable left ventricular volume measurements to the angiocardiographic method in patients with various disorders?

Population

63 patients with various disorders, aged 6 weeks to 58 years

Comparison

Fiberoptic indicator-dilution technique using… vs Angiocardiographic method

Design

Cross-sectional

Authors

PHPaul G. HugenholtzAmes Research Center HWHenry R. WagnerDuke University HSH. SandlerAmes Research Center

Discussion

Member takes

Implication

Fiberoptic LV volume estimates show strong correlation but systematic bias; leaves open whether regression-adjusted values can replace angiography in practice.

Key Points

To compare left ventricular volume, stroke volume, and ejection fraction measurements obtained by fiberoptic indicator-dilution against standard angiocardiography in vivo.
Measured end-diastolic volumes, stroke volumes, and ejection fractions in rapid succession using fiberoptic indicator-dilution and angiocardiography in 63 patients aged 6 weeks to 58 years.
Analyzed stroke volume, ejection fraction, and end-systolic volume in a subgroup of 41 patients with nonregurgitant lesions across heart rates ranging from 55 to 179 beats/min.
End-diastolic volume showed high correlation between modalities (r=0.965), though fiberoptic indicator-dilution yielded higher mean values (106.3 ml/m²) than angiocardiography (92.5 ml/m²).
Correlations in 41 nonregurgitant patients were r=0.808 for stroke volume, r=0.824 for ejection fraction, and r=0.950 for end-systolic volume across chamber volumes spanning 31.0 to 478.5 ml/m².

Structured PICO

Does the fiberoptic indicator-dilution technique provide comparable left ventricular volume measurements to the angiocardiographic method in patients with various disorders?

Population

63 patients with various disorders, aged 6 weeks to 58 years (subset of 41 patients with nonregurgitant lesions for stroke volumes, ejection fractions, and end-systolic volumes)

Intervention

Fiberoptic indicator-dilution technique using indocyanine green

Comparator

Angiocardiographic method

Outcome

Agreement in end-diastolic volumes, stroke volumes, and ejection fractions between the two methodssurrogate

The fiberoptic indicator-dilution technique shows strong correlation with angiocardiography for measuring left ventricular volumes, allowing for interchangeable use via regression equations.

Cite This Study

Hugenholtz et al. (1968) studied this question.

synapsesocial.com/papers/6a71a528e5469ee92be21298 https://doi.org/10.1161/01.cir.37.4.489

View Full Paper

Ask AI

Bookmark

Implication

Fiberoptic LV volume estimates show strong correlation but systematic bias; leaves open whether regression-adjusted values can replace angiography in practice.

The In Vivo Determination of Left Ventricular Volume

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The In Vivo Determination of Left Ventricular Volume

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider