Why the study?
Does the indicator dilution method accurately measure left ventricular volumes compared to a radiographic method in dogs?
Does the indicator dilution method accurately measure left ventricular volumes compared to a radiographic method in dogs?
The study demonstrates that estimations of left ventricular volume based on the washout of an indicator dye contain a fundamental error when compared to radiographic methods.
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Indicator dilution may inaccurately estimate LV volumes versus radiography in dogs; challenges consensus on method validity and leaves clinical translation open.
In each of 12 mongrel dogs, data for end-diastolic volume, end-systolic volume, and stroke volume of the left ventricle were obtained by two independent methods: the indicator dilution method and a radiographic method. While the values for stroke volume showed good agreement between the two methods, a significant and directionally constant difference was found between values for end-diastolic volume and end-systolic volume calculated by the two different methods. This was observed in dogs with fast heart rates (exceeding 150 beats/min), as well as in dogs with heart rates of about 100 beats/min. The findings strongly suggest that a fundamental error is present in estimations of volume based on the washout of an indicator dye.
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Hallermann et al. (1963) studied this question.
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