What question did this study set out to answer?

This study aims to explore the relationship between hippocampal blood flow abnormalities and cognitive symptoms in chronic heart failure patients.

January 1, 2016Circulation JournalOpen Access

Hippocampal Blood Flow Abnormality Associated With Depressive Symptoms and Cognitive Impairment in Patients With Chronic Heart Failure

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Why the study?

Is symptomatic Stage C chronic heart failure associated with reduced hippocampal cerebral blood flow and worse cognitive/depressive symptoms compared to asymptomatic Stage B structural heart disease?

Population

80 patients aged 45-90 years, comprising 40 Stage C patients with past or current chronic heart failure…

Design

Cross-sectional, Psychological tests were performed by well-experienced…

Authors

HSHideaki SuzukiNew Mexico State University YMYasuharu MatsumotoInterventional Cardiology HOHideki OtaTohoku University Hospital

Discussion

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Implication

Hypothesis-generating for hippocampal perfusion as HF treatment target; prospective trials needed before clinical adoption.

Key Points

This study aims to explore the relationship between hippocampal blood flow abnormalities and cognitive symptoms in chronic heart failure patients.
Enrolled 40 Stage C patients with chronic heart failure and 40 Stage B control patients with structural heart disease.
Measured cerebral blood flow in the hippocampus using brain MRI.
Assessed depressive symptoms and memory using Geriatric Depression Scale and Wechsler Memory Scale-revised.
Hippocampal blood flow was lower in Stage C patients compared to Stage B (P=0.029).
Significant association found between hippocampal blood flow and depressive symptoms (GDS) or delayed memory scores (all P<0.05).
Stage C patients with lower hippocampal blood flow exhibited higher GDS scores and lower immediate and delayed memory scores (all P<0.05).

Structured PICO

Is symptomatic Stage C chronic heart failure associated with reduced hippocampal cerebral blood flow and worse cognitive/depressive symptoms compared to asymptomatic Stage B structural heart disease?

Population

80 patients aged 45-90 years, comprising 40 Stage C patients with past or current chronic heart failure (CHF) symptoms and 40 Stage B patients with structural heart disease but no CHF symptoms. Exclusions: contraindication to cardiac MRI, unstable cardiac function, past history affecting cerebral blood flow or brain structure.

Outcome

Cerebral blood flow (CBF) in the 4 anterior-posterior segments of the hippocampus, measured using brain MRI analysissurrogate

Hippocampal blood flow abnormalities in the posterior segment are associated with depressive symptoms and cognitive impairment in patients with symptomatic chronic heart failure.

Limitations

Focused on abnormalities of the hippocampal CBF based on previous study in CHF rats; possible alterations in other brain regions remain to be examined
CHF patients have cardiovascular risk factors and hypertensive drugs that could affect brain structural and functional differences

Cite This Study

Suzuki et al. (2016) studied this question.

synapsesocial.com/papers/6a73eba7cd7b40c8110dd9e1 https://doi.org/10.1253/circj.cj-16-0367

Topics

Heart failure HFrEF treatment

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Hippocampal Blood Flow Abnormality Associated With Depressive Symptoms and Cognitive Impairment in Patients With Chronic Heart Failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Topics

Hippocampal Blood Flow Abnormality Associated With Depressive Symptoms and Cognitive Impairment in Patients With Chronic Heart Failure

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

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Topics

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