January 1, 2004Journal of General Virology

A murine oral enterovirus 71 infection model with central nervous system involvement

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Population

Neonatal mice

Design

Preclinical

Follow-up

Up to 78 hours post-infection for kinetic studies

Authors

YCYi‐Chun ChenCheng Hsin General Hospital CYChun-Keung YuNational Cheng Kung University YWYa-Fang WangNational Health Research Institutes

Discussion

Member takes

Implication

Neonatal mouse model of oral EV71 infection established; extends preclinical pathogenesis tools while leaving human translation open.

Structured PICO

Population

Neonatal mice

Intervention

Oral administration of Enterovirus 71 (EV71) virus

Outcome

Establishment of EV71 infection model with CNS involvement (manifested by skin rash, hind limb paralysis, death, and viral replication in organs)surrogate

The study successfully established a neonatal mouse model of oral EV71 infection that replicates CNS involvement and transmission, providing a tool for studying viral pathogenesis.

Cite This Study

Chen et al. (2004) studied this question.

synapsesocial.com/papers/6a73ecb08cee7e0fe6a8c33f https://doi.org/10.1099/vir.0.19423-0

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A murine oral enterovirus 71 infection model with central nervous system involvement

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A murine oral enterovirus 71 infection model with central nervous system involvement

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider