What question did this study set out to answer?

To prospectively evaluate the diagnostic accuracy, clinical utility, and cost-effectiveness of F-18 sodium fluoride PET versus SPECT and planar bone scintigraphy for detecting bone metastases in lung cancer.

December 1, 2003Journal of Bone and Mineral ResearchOpen Access

F-18 NaF PET for Detection of Bone Metastases in Lung Cancer: Accuracy, Cost-Effectiveness, and Impact on Patient Management

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Authors

MHMartin HetzelKrankenhaus vom Roten Kreuz CACoskun ArslandemirUniversität Ulm HKHans-Helmut KönigUniversität Hamburg

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Implication

Prospective cohort study demonstrates superior diagnostic accuracy of F-18 NaF PET over SPECT in lung cancer, highlighting trade-offs with higher incremental costs.

Key Points

To prospectively evaluate the diagnostic accuracy, clinical utility, and cost-effectiveness of F-18 sodium fluoride PET versus SPECT and planar bone scintigraphy for detecting bone metastases in lung cancer.
Prospective evaluation of 103 patients with newly diagnosed lung cancer who underwent planar bone scintigraphy (BS), vertebral SPECT, and F-18 NaF PET.
Diagnostic accuracy assessed using receiver operating characteristic (ROC) analysis, and cost-effectiveness determined via decision-analysis modeling and German Hospital Association reimbursement schedules.
Area under the ROC curve was 0.771 for BS, 0.875 for SPECT, and 0.989 for F-18 PET (p < 0.05), with false-negative results in 13 of 33 metastatic cases for BS, 4 for SPECT, and 2 for F-18 PET.
Imaging findings prompted changes in clinical management in 8 patients (7.8%) with SPECT and 10 patients (9.7%) with F-18 PET.
Incremental costs per additional correctly diagnosed patient relative to BS were €1,272 for SPECT and €2,861 for F-18 PET, with F-18 PET becoming more cost-effective than SPECT below a cost threshold of €345.

Cite This Study

Hetzel et al. (2003) studied this question.

synapsesocial.com/papers/6a73ecb0d080559b4669f948 https://doi.org/10.1359/jbmr.2003.18.12.2206

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Implication

Prospective cohort study demonstrates superior diagnostic accuracy of F-18 NaF PET over SPECT in lung cancer, highlighting trade-offs with higher incremental costs.

F-18 NaF PET for Detection of Bone Metastases in Lung Cancer: Accuracy, Cost-Effectiveness, and Impact on Patient Management

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Cite This Study

F-18 NaF PET for Detection of Bone Metastases in Lung Cancer: Accuracy, Cost-Effectiveness, and Impact on Patient Management

Discussion

Member takes

Implication

Key Points

Cite This Study

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