The methanol extract of the leaves of Gynura procumbens was partitioned between chloroform, ethyl acetate and n -butanol. Qualitative HPLC identification of the major flavonoid constituents in the n -butanol fraction and separation of standard mixture of isolated compounds from the n -butanol fraction are given. Blood glucose levels in streptozotocin-induced type 2 diabetic rats were reduced by the administration of 1 g/kg of the n -butanol fraction. The results were compared with glibenclamide used as standard drug. The fraction produced no significant effect in normal rats.
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Akowuah et al. (2002) studied this question.
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