February 15, 2002Journal of Clinical Oncology
Adrenocortical Carcinoma: Clinical, Morphologic, and Molecular Characterization
Population
124 patients with adrenocortical carcinoma, including histopathologic slides for 67 primary tumors, tissue…
Design
Cohort
Follow-up
median 4.7 years
Authors
Discussion
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Implication
Adverse histologic parameters stratify survival in adrenocortical carcinoma; supports risk stratification but should not yet alter practice.
Structured PICO
P
Population
124 patients with adrenocortical carcinoma (ACC), including histopathologic slides for 67 primary tumors, tissue specimens for 74 patients (38 primary and 36 metastatic tumors), and 38 normal adrenal tissue samples.
O
Outcome
Disease-specific survival (DSS)hard clinical
Meticulous morphologic evaluation, mitotic count, and tumor stage are essential prognostic factors in adrenocortical carcinoma, which exhibits significant molecular heterogeneity.
Cite This Study
Stojadinovic et al. (2002) studied this question.