November 1, 1997Hypertension
Insulin Resistance, Hyperinsulinemia, and Blood Pressure
Why the study?
Is insulin resistance independently associated with higher blood pressure in normotensive, nondiabetic subjects?
Population
333 nondiabetic men and women, ages 18 to 70 years, BMI 18.4 to 39.8 kg/m², with normal blood pressure, from…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Association warrants no practice change in normotensives; leaves open causal role of insulin resistance pending prospective studies.
Structured PICO
Is insulin resistance independently associated with higher blood pressure in normotensive, nondiabetic subjects?
P
Population
333 nondiabetic men and women, ages 18 to 70 years, BMI 18.4 to 39.8 kg/m², with normal blood pressure (<140/90 mm Hg), from 20 European centers.
O
Outcome
Systolic and diastolic blood pressuresurrogate
In normotensive, nondiabetic Europeans, insulin sensitivity and age are mutually independent correlates of blood pressure, suggesting distinct influences of insulin resistance and compensatory hyperinsulinemia on blood pressure.
Cite This Study
Ferrannini et al. (1997) studied this question.